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adults who have ever used electronic cigarettes more than quadrupled from 0.6% in 2009 to 2.7% in 2010 with an estimated number of current electronic cigarette users of about 2.5 million [96]
Several EVALI case series were first described beginning around September 2019
Since the vast majority of smokers begin smoking before the age of 21, Tobacco 21 laws are able to reduce smoking and other tobacco use among young people and have been shown effective, publicly supported and to have minimal, short-term economic impact.27 A 2015 report by the National Academy of Medicine estimated that if a nationwide Tobacco 21 rule was implemented, it would result in 249,000 fewer premature deaths, 45,000 fewer deaths from lung cancer and 4.2 million fewer lost life-years among Americans born between 2010 and 2019
[DOI] [PubMed] [Google Scholar] 88.Staretz ME, Murphy SE, Patten CJ, Nunes MG, Koehl W, Amin S, Koenig LA, Guengerich FP, Hecht SS
While we are convinced that the totality of evidence demonstrates that switching completely to THS presents less risk of harm compared to continued smoking, we will continue to work closely with the agency to determine what information would allow the FDA to conclude that the specific and statutory requirements in the U.S